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Melissa Scala, MD

  • Melissa Lewis Scala

Specialties

Neonatology

Work and Education

Professional Education

Georgetown University School of Medicine, Washington, DC, 5/24/1997

Internship

University of Alabama at Birmingham, Birmingham, AL, 6/30/1999

Residency

University of Alabama at Birmingham, Birmingham, AL, 6/30/2001

Fellowship

Georgetown University Hospital, Washington, DC, 12/31/2012

Board Certifications

Neonatology, American Board of Pediatrics

Pediatrics, American Board of Pediatrics

Services

Neonatology

All Publications

Pilot study of dornase alfa (Pulmozyme) therapy for acquired ventilator-associated infection in preterm infants. Pediatric pulmonology Scala, M., Hoy, D., Bautista, M., Palafoutas, J. J., Abubakar, K. 2017

Abstract

Evaluate the feasibility, safety, and efficacy of adjunctive treatment with dornase alfa in preterm patients with ventilator-associated pulmonary infection (VAPI) compared to standard care.We hypothesize that therapy with dornase alfa will be safe and well tolerated in the preterm population with no worsening of symptoms, oxygen requirement, or need for respiratory support.Prospective, randomized, blinded, pilot study comparing adjunctive treatment with dornase alfa to sham therapy. In addition to standard care, infants were randomized to receive dornase alfa 2.5mg nebulized via endotracheal tube (ETT) every 12hr for 7 days or sham therapy. ETT secretion gram stain and culture and chest X-ray (CXR) findings were evaluated. Respiratory support data were downloaded from the ventilator.Fourteen infants developed VAPI between 2012 and 2014; 11 enrolled in the study. Six received dornase alfa and five received sham therapy. Average gestational age at birth was 25 weeks and age at study entry was 31 days. There were no differences in demographics, ETT white blood cell count (WBC), CXR, or mean airway pressure (MAP) between the two groups. There was a trend towards decreased oxygen requirement (FiO2) in the treatment group that did not reach statistical significance. No side effects were observed in the treatment group.Treatment with dornase alfa is safe and treated infants had some improvement in FiO2 requirement but no improvement in MAP. A larger randomized trial is needed to evaluate the efficacy of this therapy. Pediatr Pulmonol. 2016; 9999:XX-XX. 2016 Wiley Periodicals, Inc.

View details for DOI 10.1002/ppul.23656

View details for PubMedID 28052587