Wen-Shin Lee, MD

View details for Web of Science ID 000554528303047

Abstract

To test the hypothesis that cataract surgery slows the apparent rate of visual field (VF) decay in primary open-angle glaucoma patients compared with rates measured during cataract progression.Retrospective cohort study.Consecutive open-angle glaucoma patients who underwent cataract surgery and who had 4 VFs and 3 years of follow-up before and after surgery were retrospectively reviewed. Mean deviation (MD) rate, visual field index (VFI) rate, pointwise linear regression (PLR), pointwise rate of change (PRC), and the Glaucoma Rate Index (GRI) were compared before and after cataract surgery.A total of 134 eyes of 99 patients were included. Median (interquartile range) follow-up was 6.5 (4.7-8.1) and 5.3 (4.0-7.3) years before and after cataract surgery, respectively. All intraocular pressure (IOP) parameters (mean IOP, standard deviation of IOP, and peak IOP) significantly improved (P < .001) after cataract surgery. All VF indices indicated an accelerated VF decay rate after cataract surgery: MD rate (-0.18 0.40 dB/year vs -0.40 0.62 dB/year, P < .001), VFI rate (-0.44% 1.09%/year vs -1.19% 1.85%/year, P < .001), GRI (-5.5 10.8 vs -13.5 21.5; P < .001), and PRC (-0.62% 2.47%/year before and -1.35% 3.71%/year after surgery; P < .001) and PLR (-0.20 0.82 dB/year before and -0.42 1.16 dB/year after surgery; P < .001) for all VF locations. Worse baseline MD and postoperative peak IOP were significantly associated with the postoperative VF decay rate and the change in the decay rate after cataract surgery.Although all IOP parameters improved after cataract surgery, VFs continued to progress. Cataract surgery does not slow the apparent rate of glaucomatous VF decay as compared to rates measured during the progression of the cataract.

View details for DOI 10.1016/j.ajo.2019.01.019

View details for Web of Science ID 000468253700003

View details for PubMedID 30703355

Abstract

The aim of the study was to determine and compare the relationship between change in simulated keratometry (K) and degree of refractive correction in wavefront-guided (WFG) and wavefront-optimized (WFO) myopic laser-assisted in situ keratomileusis (LASIK).A total of 51 patients were prospectively randomized to WFG LASIK in one eye and WFO LASIK in the contralateral eye at the Byers Eye Institute, Stanford University. Changes in simulated K and refractive error were determined at 1 year post-operatively. Linear regression was employed to calculate the slope of change in simulated K (K) for change in refractive error (SE). The mean ratio (K/SE) was also calculated.The ratio of K to SE was larger for WFG LASIK compared to WFO LASIK when comparing the slope (K/SE) as determined by linear regression (0.85 vs 0.83, p = 0.04). Upon comparing the mean ratio (K/SE), subgroup analysis revealed that K/SE was larger for WFG LASIK for refractive corrections of >3.00 D and >4.00 D (0.89 vs 0.83; p = 0.0323 and 0.88 vs 0.83; p = 0.0466, respectively). Both linear regression and direct comparison of the mean ratio (K/SE) for refractive corrections <4.00 D and >4.00 D revealed no difference in K/SE between smaller and larger refractive corrections.WFO LASIK requires a smaller amount of corneal flattening compared to WFG LASIK for a given degree of refractive correction. For both, there was no significant difference in change in corneal curvature for a given degree of refractive error between smaller and larger corrections.

View details for PubMedID 29636597

Abstract

The purpose of this study was to evaluate the long-term efficacy of phototherapeutic keratectomy (PTK) in treating epithelial basement membrane dystrophy (EBMD).Preoperative and postoperative records were reviewed for 58 eyes of 51 patients with >3 months follow-up (range 3-170 months) treated for EBMD with PTK after failure of conservative medical treatment at Byers Eye Institute of Stanford University. Symptoms, clinical findings, and corrected distance visual acuity (CDVA) were assessed. The primary outcome measure was symptomatic recurrence as measured by erosions or visual complaints >3 months after successful PTK.For eyes with visual disturbances (n=30), preoperative CDVA wa20/32 (0.24 Log-MAR, SD 0.21) and postoperative CDVA was ~20/25 (0.07 LogMAR, SD 0.12; P<0.0001). Twenty-six eyes (86.7%) responded to treatment, with symptomatic recurrence in 6 eyes (23.1%) at an average of 37.7 months (SD 42.8). For eyes with painful erosions (n=29), preoperative CDVA was ~20/25 (0.12, SD 0.19) and postoperative CDVA was ~20/20 (0.05. SD 0.16; P=0.0785). Twenty-three eyes (79.3%) responded to treatment, with symptomatic recurrence in 3 eyes (13.0%) at an average of 9.7 months (SD 1.5). The probability of being recurrence free after a successful treatment for visual disturbances and erosions at 5 years postoperatively was estimated at 83.0% (95% confidence interval 68.7%-97.0%) and 88.0% (95% confidence interval 65.3%-96.6%), respectively.The majority of visual disturbances and painful erosions associated with EBMD respond to PTK. For those with a treatment response, symptomatic relief is maintained over long-term follow-up.

View details for DOI 10.2147/OPTH.S122870

View details for PubMedID 28031698

Abstract

To determine the relationship between change in simulated keratometry and corrected refractive error in both wavefront-guided and wavefront-optimized myopic photorefractive keratectomy (PRK), and to determine whether there is a difference in this relationship between these two ablation profiles.Sixty-eight patients received wavefront-guided PRK in one eye and wavefront-optimized PRK in the contralateral eye. The changes in simulated keratometry and corresponding refractive changes for both were determined at 1 year postoperatively. Linear regression was employed to calculate the slope of change in simulated keratometry (K) for change in refractive error (SE) for both wavefront-guided and wavefront-optimized PRK and compared. The mean ratio K/SE was also calculated for both wavefront-guided and wavefront-optimized PRK and compared.There was no significant difference in the ratio of K to SE between wavefront-optimized and wavefront-guided PRK by both linear regression modeling and comparison of the mean ratio K/SE. Linear regression modeling revealed that the ratio of K/SE was greater for small amounts of change in refractive error and smaller for large amounts of change in refractive error. This trend was only statistically significant for the wavefront-optimized group when comparing the means of the ratio K/SE (P = .0287).The change in corneal curvature induced for a given degree of refractive correction was similar for both wavefront-optimized and wavefront-guided PRK. For both, a proportionally smaller amount of corneal flattening was required for larger degrees of refractive correction compared to smaller degrees. [J Refract Surg. 2016;32(8):542-548.].

View details for DOI 10.3928/1081597X-20160525-01

View details for Web of Science ID 000384899900005

View details for PubMedID 27505315