Congenitally Corrected Transposition of the Great Arteries (CCTGA)

At Stanford Children’s Health, we are dedicated to providing the highest level of specialty care and surgical repair for individuals of all ages, from birth through adulthood, with congenitally corrected transposition of the great arteries (CCTGA)—a rare and complex form of congenital heart disease. Besides providing highly complex heart surgery for CCTGA, we manage the clinical care for CCTGA to help our patients feel healthy and live their best life. 

Understanding CCTGA

  • CCTGA is also known as L-transposition of the great arteries (L-TGA) and is sometimes described as atrioventricular and ventriculoarterial discordance, or double discordance.
  • The normal heart has two muscular pumping chambers, called the right and left ventricles. These two ventricles are not identical in structure or function. They each have evolved and developed to serve very specific purposes. The role of the left ventricle is to pump blood to the body. To do this, it must pump at high pressure. The left ventricle is designed for this role and performs it very well. On the other hand, the role of the right ventricle is to pump blood to the lungs. The right ventricle has a much easier task than the left ventricle, because it only has to pump blood at low pressure, typically about 15% of the pressure that the left ventricle uses. The right ventricle is designed to pump at this lower pressure and is structurally not suited to pump at higher pressure.
  • For babies born with CCTGA, the right and left ventricles are switched in position and in roles. As a result, the right ventricle must take on the more demanding role of pumping the blood to the body at high pressure. This puts a strain on the right ventricle, which in many cases leads to serious heart problems.
  • About 90% of babies born with CCTGA will have additional structural abnormalities of the heart. These additional abnormalities also frequently lead to serious heart problems.
  • In the United States, 0.5% to 1% of all babies born with heart defects have CCTGA.
  • Most people born with CCTGA eventually need heart surgery.

Normal heart vs. CCTGA heart

A normal heart, on the left, compared to a CCTGA heart on the right. 

CCTGA program highlights

  • Expertise in complex CCTGA surgery. At Stanford Children’s Health, we perform more than 700 pediatric heart surgeries each year with excellent outcomes despite the high complexity of cases we treat. For CCTGA in particular, we carry out a complicated surgery that reroutes the blood within the heart and restores the roles of the right and left ventricles. We are one of a few programs nationwide that offers the anatomic double-switch repair, which our team of renowned heart specialists has been performing for the past two decades.
  • Proven results. Our program has managed more than 100 patients with CCTGA. Our unique approach to the double-switch repair may prevent or delay many of the major complications seen in CCTGA patients.
  • Individualized care to improve quality of life. Every child with CCTGA is unique. We have developed clear criteria to help guide care decisions for each patient, taking into account your child’s unique condition and health needs. Together with your child’s cardiologist, we individually tailor care over your child’s lifetime to determine when and if surgery is the right next step and how best to enhance your child’s health and well-being.