Platelet-rich Plasma for Patients with Recurrent Implantation Failure: A Prospective Randomized Pilot Study

Recurrent implantation failure (RIF), a condition in which repetitive cycles of IVF are unsuccessful even though good quality embryos have been transferred, presents a significant clinical challenge to fertility clinics worldwide. We are currently conducting a study to use intrauterine infusion of autologous platelet-rich plasma (PRP) to improve embryo transfer outcomes among RIF patients. We are interested to see if the effect of PRP on endometrium that we observed in our preclinical studies will translate into improved endometrial function in RIF patients, as measured by improved embryo implantation and ongoing pregnancy rates. (Currently there is no definitive established marker for proper endometrial function other than successful implantation and sustained pregnancy.)

All patients of any ethnic background who have undergone at least two embryo transfers without a successful pregnancy may be eligible to participate in the study. Please let your physician know you are interested, or contact Lusine Aghajanova, MD, at Stanford Medicine Fertility and Reproductive Health Services.

You may be eligible if you:

  • Are between the ages of 18 and 45
  • Have a history of two or more unsuccessful embryo transfers
  • Have a normal uterine cavity, established within 12 months by hysteroscopy or saline infusion sonogram
  • Are planning to undergo in vitro fertilization with an embryo transfer at Stanford Medicine Fertility and Reproductive Health Services

Study participation involves:

  • Preparation for a frozen embryo transfer (FET) cycle based on a specific protocol selected for you by your primary doctor
  • Additional blood work for isolation of platelets and creation of platelet-rich plasma (PRP)
  • Ultrasound prior to intrauterine PRP infusion
  • Two visits for blood draw, ultrasounds and PRP infusion, which may coincide with your routine clinic visits

Enrolled participants will receive the blood draw, PRP isolation and PRP infusion free of charge.

For more information, please contact:

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