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Jeanne Shen, MD

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Especialidades médicas y/o especialidades quirúrgicas

Anatomic & Clinical Pathology

Trabajo y educación

Educación

Washington University in St Louis Registrar, St Louis, MO, 5/21/2010

Últimos años de residencia

Brigham and Women's Hospital Pathology Residency, Boston, MA, 6/30/2014

Subespecialidad

Brigham and Women's Hospital Dept of Pathology, Boston, MA, 6/30/2017

Certificado(s) de especialidad

Anatomic & Clinical Pathology, American Board of Pathology

Todo Publicaciones

Deep learning predicts postsurgical recurrence of hepatocellular carcinoma from digital histopathologic images. Scientific reports Yamashita, R. n., Long, J. n., Saleem, A. n., Rubin, D. L., Shen, J. n. 2021; 11 (1): 2047

Abstract

Recurrence risk stratification of patients undergoing primary surgical resection for hepatocellular carcinoma (HCC) is an area of active investigation, and several staging systems have been proposed to optimize treatment strategies. However, as many as 70% of patients still experiencetumor recurrence at 5years post-surgery. We developed and validated a deep learning-based system (HCC-SurvNet) that provides risk scores for disease recurrence after primary resection, directly from hematoxylin and eosin-stained digital whole-slide images of formalin-fixed, paraffin embedded liver resections. Our model achieved concordance indices of 0.724 and 0.683 on the internal and external test cohorts, respectively, exceeding the performance of the standard Tumor-Node-Metastasis classification system. The model's risk score stratified patients into low- and high-risk subgroupswith statistically significant differences in their survival distributions, and was an independent risk factor for post-surgical recurrence in both test cohorts. Our results suggest that deep learning-based models can provide recurrence risk scores which may augment current patient stratification methods and help refine the clinical management of patients undergoing primary surgical resection for HCC.

View details for DOI 10.1038/s41598-021-81506-y

View details for PubMedID 33479370

View details for PubMedCentralID PMC7820423

Deep learning for the prediction of microsatellite instability in colorectal cancer: a diagnostic study The Lancet Oncology Yamashita, R., Long, J., Longacre, T., Peng, L., Berrry, G. J., Martin, B., Higgins, J. P., Rubin, D. L., Shen, J. 2021; 22 (1): 132-141
Deep learning assistance for the histopathologic diagnosis of Helicobacter pylori Intelligence-Based Medicine Zhou, S., Marklund, H., Blaha, O., Desai, M., Martin, B., Bingham, D., Berry, G. J., Gomulia, E., Ng, A. Y., Shen, J. 2020
Impact of a deep learning assistant on the histopathologic classification of liver cancer. NPJ digital medicine Kiani, A. n., Uyumazturk, B. n., Rajpurkar, P. n., Wang, A. n., Gao, R. n., Jones, E. n., Yu, Y. n., Langlotz, C. P., Ball, R. L., Montine, T. J., Martin, B. A., Berry, G. J., Ozawa, M. G., Hazard, F. K., Brown, R. A., Chen, S. B., Wood, M. n., Allard, L. S., Ylagan, L. n., Ng, A. Y., Shen, J. n. 2020; 3: 23

Abstract

Artificial intelligence (AI) algorithms continue to rival human performance on a variety of clinical tasks, while their actual impact on human diagnosticians, when incorporated into clinical workflows, remains relatively unexplored. In this study, we developed a deep learning-based assistant to help pathologists differentiate between two subtypes of primary liver cancer, hepatocellular carcinoma and cholangiocarcinoma, on hematoxylin and eosin-stained whole-slide images (WSI), and evaluated its effect on the diagnostic performance of 11 pathologists with varying levels of expertise. Our model achieved accuracies of 0.885 on a validation set of 26 WSI, and 0.842 on an independent test set of 80 WSI. Although use of the assistant did not change the mean accuracy of the 11 pathologists (p=0.184, OR=1.281), it significantly improved the accuracy (p=0.045, OR=1.499) of a subset of nine pathologists who fell within well-defined experience levels (GI subspecialists, non-GI subspecialists, and trainees). In the assisted state, model accuracy significantly impacted the diagnostic decisions of all 11 pathologists. As expected, when the model's prediction was correct, assistance significantly improved accuracy (p=0.000, OR=4.289), whereas when the model's prediction was incorrect, assistance significantly decreased accuracy (p=0.000, OR=0.253), with both effects holding across all pathologist experience levels and case difficulty levels. Our results highlight the challenges of translating AI models into the clinical setting, and emphasize the importance of taking into account potential unintended negative consequences of model assistance when designing and testing medical AI-assistance tools.

View details for DOI 10.1038/s41746-020-0232-8

View details for PubMedID 32140566

View details for PubMedCentralID PMC7044422

Changes in the dielectric spectra of murine colon during neoplastic progression Biomedical Physics & Engineering Express Sabuncu*, A. C., Shen*, J., Zaki, M., Beskok, A., (*equal contribution) 2018; 4 (3): 035003

View details for DOI 10.1088/2057-1976/aaad81

Pathology and Molecular Pathology of Colorectal Cancer Pathology and Epidemiology of Cancer: Molecular Underpinnings Poulin, E. J., Shen, J., Gierut, J. J., Haigis, K. M. Springer International. 2017; 1: 409446
Learning domain-agnostic visual representation for computational pathology using medically-irrelevant style transfer augmentation Arxiv Yamashita, R., Long, J., Banda, S., Shen, J., Rubin, D. L. 2021

View details for DOI 10.1007/s10620-019-06003-9

View details for PubMedID 31919637

In the Thick of It: The Many Faces of Collagenous Gastritis. Digestive diseases and sciences Singh, S., Jing, E., Shen, J. 2020

Abstract

Enteric glia are a distinct population of peripheral glial cells in the enteric nervous system that regulate intestinal homeostasis, epithelial barrier integrity, and gut defense. Given these unique attributes, we investigated the impact of enteric glia depletion on tumor development in azoxymethane/dextran sodium sulfate (AOM/DSS)-treated mice, a classical model of colorectal cancer (CRC). Depleting GFAP+ enteric glia resulted in a profoundly reduced tumor burden in AOM/DSS mice and additionally reduced adenomas in the ApcMin/+ mouse model of familial adenomatous polyposis, suggesting a tumor-promoting role for these cells at an early premalignant stage. This was confirmed in further studies of AOM/DSS mice, as enteric glia depletion did not affect the properties of established malignant tumors but did result in a marked reduction in the development of precancerous dysplastic lesions. Surprisingly, the protective effect of enteric glia depletion was not dependent on modulation of anti-tumor immunity or intestinal inflammation. These findings reveal that GFAP+ enteric glia play a critical pro-tumorigenic role during early CRC development and identify these cells as a potential target for CRC prevention.

View details for DOI 10.3389/fonc.2020.595892

View details for PubMedCentralID PMC7691584

Enteric Glia Play a Critical Role in Promoting the Development of Colorectal Cancer Frontiers in Oncology Yuan, R., Bhattacharya, N., Kenkel, J. A., Shen, J., DiMaio, M. A., Bagchi, S., Prestwood, T. R., Habtezion, A., Engleman, E. G. 2020; 10: 595892
Hispanic/Latino gastric adenocarcinoma patients have distinct molecular profiles including a high rate of germline CDH1 mutations Cancer Res, 2020 Apr 8. pii: canres.2918.2019 [Epub ahead of print] Wang, S. C., Yeu, Y., Hammer, S. T., Xiao, S., Zhu, M., Hong, C., Yoon, L. Y., Nassour, I., Shen, J., Agarwal, D., Reznik, . I., Mansour, J. C., Yopp, A. C., Zhu, H., Hwang, T., Porembka, M. R. 2020
Deep learning predicts post-surgical recurrence of hepatocellular carcinoma from digital whole-slide images MedRxiv Yamashita, R., Long, J., Saleem, A., Rubin, D. L., Shen, J. 2020
Deep learning-based Helicobacter pylori detection: A diagnostic pathology study MedRxiv Zhou, S., Marklund, H., Blaha, O., Desai, M., Martin, B., Bingham, D., Berry, G. J., Gomulia, E., Ng, A. Y., Shen, J. 2020

Abstract

OBJECTIVE: ARID1A is commonly mutated in pancreatic ductal adenocarcinoma (PDAC), but the functional effects of ARID1A mutations in the pancreas are unclear. Understanding the molecular mechanisms that drive PDAC formation may lead to novel therapies.DESIGN: Concurrent conditional Arid1a deletion and Kras activation mutations were modelled in mice. Small-interfering RNA (siRNA) and CRISPR/Cas9 were used to abrogate ARID1A in human pancreatic ductal epithelial cells.RESULTS: We found that pancreas-specific Arid1a loss in mice was sufficient to induce inflammation, pancreatic intraepithelial neoplasia (PanIN) and mucinous cysts. Concurrent Kras activation accelerated the development of cysts that resembled intraductal papillary mucinous neoplasm. Lineage-specific Arid1a deletion confirmed compartment-specific tumour-suppressive effects. Duct-specific Arid1a loss promoted dilated ducts with occasional cyst and PDAC formation. Heterozygous acinar-specific Arid1a loss resulted in accelerated PanIN and PDAC formation with worse survival. RNA-seq showed that Arid1a loss induced gene networks associated with Myc activity and protein translation. ARID1A knockdown in human pancreatic ductal epithelial cells induced increased MYC expression and protein synthesis that was abrogated with MYC knockdown. ChIP-seq against H3K27ac demonstrated an increase in activated enhancers/promoters.CONCLUSIONS: Arid1a suppresses pancreatic neoplasia in a compartment-specific manner. In duct cells, this process appears to be associated with MYC-facilitated protein synthesis.

View details for PubMedID 30315093

Plexus Convolutional Neural Network (PlexusNet): A novel neural network architecture for histologic image analysis ArXiv Eminaga, O., Abbas, M., Kunder, C., , Loening, A. M., Shen, J., Brooks, J. D., Langlotz, C. P., Rubin, D. L. 2019

Abstract

Previous approaches to defining subtypes of colorectal carcinoma (CRC) and other cancers based on transcriptomes have assumed the existence of discrete subtypes. We analyze gene expression patterns of colorectal tumors from a large number of patients to test this assumption and propose an approach to identify potentially a continuum of subtypes that are present across independent studies and cohorts.We examine the assumption of discrete CRC subtypes by integrating 18 published gene expression datasets and >3700 patients, and contrary to previous reports, find no evidence to support the existence of discrete transcriptional subtypes. Using a meta-analysis approach to identify co-expression patterns present in multiple datasets, we identify and define robust, continuously varying subtype scores to represent CRC transcriptomes. The subtype scores are consistent with established subtypes (including microsatellite instability and previously proposed discrete transcriptome subtypes), but better represent overall transcriptional activity than do discrete subtypes. The scores are also better predictors of tumor location, stage, grade, and times of disease-free survival than discrete subtypes. Gene set enrichment analysis reveals that the subtype scores characterize T-cell function, inflammation response, and cyclin-dependent kinase regulation of DNA replication.We find no evidence to support discrete subtypes of the CRC transcriptome and instead propose two validated scores to better characterize a continuity of CRC transcriptomes.

View details for DOI 10.1186/s13059-018-1511-4

View details for Web of Science ID 000445752300001

View details for PubMedID 30253799

View details for PubMedCentralID PMC6154428

Deep Learning for the Digital Pathologic Diagnosis of Cholangiocarcinoma and Hepatocellular Carcinoma: Evaluating the Impact of a Web-based Diagnostic Assistant 2019 Conference on Neural Information Processing Systems (NeurIPS), Machine Learning for Health (ML4H) Uyumazturk, B., Kiani, A., Rajpurkar, P., Wang, A., Ball, R. L., Gao, R., Yu, Y., Jones, E., Langlotz, C. P., Martin, B., Berry, G. J., Ozawa, M. G., Hazard, F. K., Brown, R. A., Chen, S. B., Wood, M., Allard, L. S., Ylagan, L., Ng, A. Y., Shen, J. 2019
SWI/SNF component ARID1A restrains pancreatic neoplasia formation. Gut Wang, S. C., Nassour, I., Xiao, S., Zhang, S., Luo, X., Lee, J., Li, L., Sun, X., Nguyen, L. H., Chuang, J., Peng, L., Daigle, S., Shen, J., Zhu, H. 2018

Abstract

There is evidence that some cancers in patients with inflammatory bowel disease (IBD) develop via the serrated pathway of carcinogenesis. This study examined the clinicopathological features and outcome of 115 IBD patients (65 with ulcerative colitis, 50 with Crohn disease), all with at least 1 serrated polyp at endoscopy or colon resection, including the presence of synchronous and metachronous conventional neoplastic lesions (dysplasia or adenocarcinoma), over an average follow-up period of 56.4 months. Conventional neoplasia was categorized as flat dysplasia (low or high grade), sporadic adenoma, adenoma-like dysplasia-associated lesion or mass, or adenocarcinoma. Overall, 97% of patients had at least 1 hyperplastic polyp (HP), 6% had a sessile serrated adenoma/polyp, and none had a traditional serrated adenoma. Eight patients (7%) had a synchronous conventional neoplastic lesion; only 1 had flat dysplasia (1%) and 2 had adenocarcinoma (2%). Thirteen patients developed a metachronous conventional neoplastic lesion, with 8 developing their conventional neoplasm within an area of previous or concurrent colitis; only 1 patient developed flat dysplasia (1%), and none developed adenocarcinoma. A higher proportion of patients with both an HP and a synchronous conventional neoplastic lesion at index developed a metachronous conventional neoplastic lesion, compared with those with an index HP only (25% versus 7%). These results suggest that IBD patients (both ulcerative colitis and Crohn disease patients) with HP have a very low risk of developing a conventional neoplastic lesion (flat dysplasia or adenocarcinoma) that would warrant surgical resection.

View details for DOI 10.1016/j.humpath.2015.16.019

View details for Web of Science ID 000362061400017

View details for PubMedID 26297256

Continuity of transcriptomes among colorectal cancer subtypes based on meta-analysis GENOME BIOLOGY Ma, S., Ogino, S., Parsana, P., Nishihara, R., Qian, Z., Shen, J., Mima, K., Masugi, Y., Cao, Y., Nowak, J. A., Shima, K., Hoshida, Y., Giovannucci, E. L., Gala, M. K., Chan, A. T., Fuchs, C. S., Parmigiani, G., Huttenhower, C., Waldron, L. 2018; 19: 142
Clinicopathological characteristics of invasive gastric Helicobacter pylori HUMAN PATHOLOGY Dudley, J., Wieczorek, T., Selig, M., Cheung, H., Shen, J., Odze, R., Deshpande, V., Zukerberg, L. 2017; 61: 19-25

Abstract

Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder characterized by oculocutaneous hypopigmentation, platelet dysfunction, and in many cases, life-threatening pulmonary fibrosis. We report the clinical course, imaging, and postmortem findings of a 38-year-old female with HPS-related progressive pulmonary fibrosis, highlighting the role of imaging in assessment of disease severity and prognosis.

View details for DOI 10.4103/2156-7514.143437

View details for PubMedID 25379352

View details for PubMedCentralID PMC4220421

Clinical, pathologic, and outcome study of hyperplastic and sessile serrated polyps in inflammatory bowel disease HUMAN PATHOLOGY Shen, J., Gibson, J. A., Schulte, S., Khurana, H., Farraye, F. A., Levine, J., Burakoff, R., Cerda, S., Qazi, T., Hamilton, M., Srivastava, A., Odze, R. D. 2015; 46 (10): 1548-1556
Clinicopathologic Significance of Macrocystic Change in Esophageal Adenocarcinoma Setia, N., Agoston, A., Shen, J., Tippawong, M., Bueno, R., Zheng, Y., Odze, R. D., Srivastava, A. NATURE PUBLISHING GROUP. 2014: 203A

Abstract

BRAF mutations are found in a subset of non-small cell lung cancers (NSCLC). We examined the clinical characteristics and treatment outcomes of patients with NSCLC harboring BRAF mutations.Using DNA sequencing, we successfully screened 883 patients with NSCLC for BRAF mutations between July 1, 2009 and July 16, 2012. Baseline characteristics and treatment outcomes were compared between patients with and without BRAF mutations. Wild-type controls consisted of patients with NSCLC without a somatic alteration in BRAF, KRAS, EGFR, and ALK. In vitro studies assessed the biologic properties of selected non-V600E BRAF mutations identified from patients with NSCLC.Of 883 tumors screened, 36 (4%) harbored BRAF mutations (V600E, 18; non-V600E, 18) and 257 were wild-type for BRAF, EGFR, KRAS, and ALK negative. Twenty-nine of 36 patients with BRAF mutations were smokers. There were no distinguishing clinical features between BRAF-mutant and wild-type patients. Patients with advanced NSCLC with BRAF mutations and wild-type tumors showed similar response rates and progression-free survival (PFS) to platinum-based combination chemotherapy and no difference in overall survival. Within the BRAF cohort, patients with V600E-mutated tumors had a shorter PFS to platinum-based chemotherapy compared with those with non-V600E mutations, although this did not reach statistical significance (4.1 vs. 8.9 months; P = 0.297). We identified five BRAF mutations not previously reported in NSCLC; two of five were associated with increased BRAF kinase activity.BRAF mutations occur in 4% of NSCLCs and half are non-V600E. Prospective trials are ongoing to validate BRAF as a therapeutic target in NSCLC.

View details for DOI 10.1158/1078-0432.CCR-13-0657

View details for Web of Science ID 000323147700025

View details for PubMedID 23833300

View details for PubMedCentralID PMC3762878

Hermansky-pudlak syndrome complicated by pulmonary fibrosis: radiologic-pathologic correlation and review of pulmonary complications. Journal of clinical imaging science Kelil, T., Shen, J., O'Neill, A. C., Howard, S. A. 2014; 4: 59-?

Abstract

BRAF mutation in colorectal cancer is associated with microsatellite instability (MSI) through its relationship with high-level CpG island methylator phenotype (CIMP) and MLH1 promoter methylation. MSI and BRAF mutation analyses are routinely used for familial cancer risk assessment. To clarify clinical outcome associations of combined MSI/BRAF subgroups, we investigated survival in 1253 rectal and colon cancer patients within the Nurses' Health Study and Health Professionals Follow-up Study with available data on clinical and other molecular features, including CIMP, LINE-1 hypomethylation, and KRAS and PIK3CA mutations. Compared with the majority subtype of microsatellite stable (MSS)/BRAF-wild-type, MSS/BRAF-mutant, MSI-high/BRAF-mutant, and MSI-high/BRAF-wild-type subtypes showed multivariable colorectal cancer-specific mortality hazard ratios of 1.60 (95% confidence interval [CI] =1.12 to 2.28; P = .009), 0.48 (95% CI = 0.27 to 0.87; P = .02), and 0.25 (95% CI = 0.12 to 0.52; P < .001), respectively. No evidence existed for a differential prognostic role of BRAF mutation by MSI status (P(interaction) > .50). Combined BRAF/MSI status in colorectal cancer is a tumor molecular biomarker for prognosic risk stratification.

View details for DOI 10.1093/jnci/djt173

View details for Web of Science ID 000322976000013

View details for PubMedID 23878352

View details for PubMedCentralID PMC3735463

Clinicopathologic significance of macrocystic change in esophageal adenocarcinoma 103rd Annual Meeting, United States and Canadian Academy of Pathology (USCAP) Setia, N., Agoston, A., Shen, J., Tippawong, M., Bueno, R., Zheng, Y., Odze, R. D., Srivastava, A. 2014: 203A

Abstract

Diffusion weighted magnetic resonance imaging has risen to the forefront of imaging for acute stroke. However, the differential diagnosis of restricted diffusion is wide and includes ischemia, metabolic derangements, infections, and highly-cellular masses. We present a case of central nervous system (CNS) candidiasis presenting radiographically as bilateral punctate areas of restricted magnetic resonance (MR) diffusion in the basal ganglia. This case illustrates the value of carefully considering the causes of restricted diffusion in the brain, notably to be broader than acute stroke and to include invasive fungal infections.

View details for DOI 10.3941/jrcr.v7i5.1319

View details for PubMedID 23705051

View details for PubMedCentralID PMC3661417

Clinical, Pathologic, and Biologic Features Associated with BRAF Mutations in Non-Small Cell Lung Cancer CLINICAL CANCER RESEARCH Cardarella, S., Ogino, A., Nishino, M., Butaney, M., Shen, J., Lydon, C., Yeap, B. Y., Sholl, L. M., Johnson, B. E., Jaenne, P. A. 2013; 19 (16): 4532-4540
Microsatellite Instability and BRAF Mutation Testing in Colorectal Cancer Prognostication JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE Lochhead, P., Kuchiba, A., Imamura, Y., Liao, X., Yamauchi, M., Nishihara, R., Qian, Z. R., Morikawa, T., Shen, J., Meyerhardt, J. A., Fuchs, C. S., Ogino, S. 2013; 105 (15): 1151-1156
Neurocandidiasis: a case report and consideration of the causes of restricted diffusion. Journal of radiology case reports Lin, D. J., Sacks, A., Shen, J., Lee, T. C. 2013; 7 (5): 1-5
HER2 Mutated Lung Adenocarcinoma Is a Distinct Molecular and Clinicopathologic Entity Shen, J., Taneja, K., Zhang, W., Dillon, D. A., Gandhi, L., Sholl, L. M. NATURE PUBLISHING GROUP. 2012: 490A
Prognostic Role of Combined MSI and BRAF Mutation Status in Colorectal Cancer: Toward Routine Clinical Use Shen, J., Morikawa, T., Fuchs, C. S., Ogino, S. NATURE PUBLISHING GROUP. 2012: 179A

Abstract

Postoperative atrial fibrillation is the most common complication after cardiac surgery. A variety of postoperative atrial fibrillation risk factors have been reported, but study results have been inconsistent or contradictory, particularly in patients with preexisting atrial fibrillation. The incidence of postoperative atrial fibrillation was evaluated in a group of 10,390 patients undergoing cardiac surgery among a comprehensive range of risk factors to identify reliable predictors of postoperative atrial fibrillation.This 20-year retrospective study examined the relationship between postoperative atrial fibrillation and demographic factors, preoperative health conditions and medications, operative procedures, and postoperative complications. Multivariate logistic regression models were used to evaluate potential predictors of postoperative atrial fibrillation.Increasing age, mitral valve surgery (odds ratio=1.91), left ventricular aneurysm repair (odds ratio=1.57), aortic valve surgery (odds ratio=1.52), race (Caucasian) (odds ratio=1.51), use of cardioplegia (odds ratio=1.36), use of an intraaortic balloon pump (odds ratio=1.28), previous congestive heart failure (odds ratio=1.28), and hypertension (odds ratio=1.15) were significantly associated with postoperative atrial fibrillation. The non-linear relationship between age and postoperative atrial fibrillation revealed the acceleration of postoperative atrial fibrillation risk in patients aged 55 years or more. In patients undergoing coronary artery bypass grafting, increasing age and previous congestive heart failure were the only factors associated with a higher risk of postoperative atrial fibrillation. There was no trend in incidence of postoperative atrial fibrillation over time. No protective factors against postoperative atrial fibrillation were detected, including commonly prescribed categories of medications.The persistence of the problem of postoperative atrial fibrillation and the modest predictability using common risk factors suggest that limited progress has been made in understanding its cause and treatment.

View details for DOI 10.1016/j.jtcvs.2010.03.011

View details for Web of Science ID 000286222800042

View details for PubMedID 20434173

View details for PubMedCentralID PMC2917532

HER2 mutated lung adenocarcinoma is a distinct molecular and clinicopathologic entity 101st Annual Meeting of the United States and Canadian Academy of Pathology (USCAP) Shen, J., Taneja, K., W, Z., Dillon, D. A., Gandhi, L., Sholl, L. M. 2012: 490A
Prognostic role of combined MSI and BRAF mutation status in colorectal cancer: Toward routine clinical use 101st Annual Meeting, United States and Canadian Academy of Pathology (USCAP) Shen, J., Morikawa, T., Kuchiba, A., Fuchs, C. S., Ogino, S. 2012: 179A
The persistent problem of new-onset postoperative atrial fibrillation: A single-institution experience over two decades JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY Shen, J., Lall, S., Zheng, V., Buckley, P., Damiano, R. J., Schuessler, R. B. 2011; 141 (2): 559-570

Abstract

For two decades, the cut-and-sew Cox-Maze III procedure was the gold standard for the surgical treatment of atrial fibrillation (AF), and proved to be effective at curing lone AF and preventing its most dreaded complication, stroke. However, this procedure was not widely adopted due to its complexity and technical difficulty. Over the last 5-10 years, the introduction of new ablation technology has led to the development of the Cox-Maze IV procedure, as well as, more limited lesion sets, with the ultimate goal of performing a minimally-invasive lesion set on the beating heart, without the need for cardiopulmonary bypass. This review summarizes the current state of the art and future directions in the surgical treatment of lone atrial fibrillation. The hope is that as we learn more about the mechanisms of AF and develop preoperative diagnostic technologies capable of precisely locating the areas responsible for AF, it will become possible to tailor specific lesion sets and ablation modalities to individual patients, making the surgical treatment of lone AF available to a larger population of patients.

View details for PubMedID 20473355

View details for PubMedCentralID PMC2868583

Acute Glomerulitis with Neutrophils May Underscore the Development of Glomerular Basement Membrane Multi-Lamination in Transplant Glomerulopathy Gaut, J. P., Shen, J., DeGuire, M., Klein, C., Liapis, H. NATURE PUBLISHING GROUP. 2011: 344A

Abstract

For two decades, the cut-and-sew Cox-maze III procedure was the gold standard for the surgical treatment of atrial fibrillation (AF) and has proven to be effective at eliminating AF. The incidence of late stroke was also very low. However, this procedure was not widely adopted owing to its complexity and technical difficulty. Over the last 5-10 years, the introduction of new ablation technology has led to the development of the Cox-maze IV procedure as well as more limited lesion sets, with the ultimate goal of performing a minimally invasive lesion set on the beating heart without the need for cardiopulmonary bypass. This review summarizes the current state of the art and future directions in the stand-alone surgical treatment of AF. The hope is that as more is learned about the mechanisms of AF and with better preoperative diagnostic technologies capable of precisely locating the areas responsible for AF, it will become possible to tailor specific lesion sets and ablation modalities to individual patients, making the surgical treatment of AF available to a larger population of patients.

View details for DOI 10.1016/j.hrthm.2009.05.019

View details for Web of Science ID 000268867800009

View details for PubMedID 19631907

View details for PubMedCentralID PMC2760330

Acute glomerulitis with neutrophils may underscore the development of glomerular basement membrane multi-lamination in transplant glomerulopathy 100th Annual Meeting, United States and Canadian Academy of Pathology (USCAP) Gaut, J. P., Shen, J., DeGuire, M., Klein, C., Liapis, H. 2011: 344A

Abstract

The temporal switch from progenitor cell proliferation to differentiation is essential for effective adult tissue repair. We previously reported the critical role of Notch signaling in the proliferative expansion of myogenic progenitors in mammalian postnatal myogenesis. We now show that the onset of differentiation is due to a transition from Notch signaling to Wnt signaling in myogenic progenitors and is associated with an increased expression of Wnt in the tissue and an increased responsiveness of progenitors to Wnt. Crosstalk between these two pathways occurs via GSK3beta, which is maintained in an active form by Notch but is inhibited by Wnt in the canonical Wnt signaling cascade. These results demonstrate that the temporal balance between Notch and Wnt signaling orchestrates the precise progression of muscle precursor cells along the myogenic lineage pathway, through stages of proliferative expansion and then differentiation, during postnatal myogenesis.

View details for DOI 10.1016/j.stem.2007.10.006

View details for Web of Science ID 000252606400011

View details for PubMedID 18371421

Surgery for Lone Atrial Fibrillation: Present State-of-the-Art. Innovations (Philadelphia, Pa.) Shen, J., Bailey, M., Damiano, R. J. 2009; 4 (5): 248-255
The surgical treatment of atrial fibrillation HEART RHYTHM Shen, J., Bailey, M. S., Damiano, R. J. 2009; 6 (8): S45-S50
A temporal switch from Notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis CELL STEM CELL Brack, A. S., Conboy, I. M., Conboy, M. J., Shen, J., Rando, T. A. 2008; 2 (1): 50-59