Palo Alto, CA 94304
Facsímil: (650) 497-8959
University of Southern California Keck School of Medicine, Los Angeles, CA, 05/14/2010
LAC+USC Internal Medicine and Pediatric Residency, Los Angeles, CA, 06/30/2014
Stanford University Hematology and Oncology Fellowship, Palo Alto, CA, 06/30/2020
Stanford University Pediatric Hematology Oncology Fellowship, Palo Alto, CA, 06/30/2020
Hematology, American Board of Internal Medicine
Internal Medicine, American Board of Internal Medicine
Pediatrics, American Board of Pediatrics
A central challenge in medicine is translating from observational understanding to mechanistic understanding, where some observations are recognized as causes for the others. This can lead not only to new treatments and understanding, but also to recognition of novel phenotypes. Here, we apply a collection of mathematical techniques (empirical dynamics), which infer mechanistic networks in a model-free manner from longitudinal data, to hematopoiesis. Our study consists of three subjects with markers for cyclic thrombocytopenia, in which multiple cells and proteins undergo abnormal oscillations. One subject has atypical markers and may represent a rare phenotype. Our analyses support this contention, and also lend new evidence to a theory for the cause of this disorder. Simulations of an intervention yield encouraging results, even when applied to patient data outside our three subjects. These successes suggest that this blueprint has broader applicability in understanding and treating complex disorders.
View details for DOI 10.1016/j.patter.2020.100138
View details for PubMedID 33336196
View details for DOI 10.1016/j.ajog.2019.11.474
View details for Web of Science ID 000504997300457
View details for Web of Science ID 000428851200243
View details for Web of Science ID 000428851200076