Aplastic anemia occurs when the bone marrow produces too few of all types of blood cells: red cells, white cells, and platelets. A reduced number of red blood cells causes the red cell number and hemoglobin (a type of protein in the red blood cells that carries oxygen to the tissues of the body) to drop. A reduced number of white blood cells causes the patient to be susceptible to infection. A reduced number of platelets can cause the blood not to clot the way it should.
Aplastic anemia in children has multiple causes. Some of these causes are idiopathic, meaning they occur sporadically for no known reason. Other causes are secondary, resulting from a previous illness or disorder. Very often there is an immunological dysfunction (immune system problem) or malignant (cancerous) change in the cells.
Many childhood cases of aplastic anemia occur sporadically for no known reason. Acquired causes, however, may include:
History of specific infectious diseases, such as hepatitis, Epstein-Barr virus (EBV), cytomegalovirus (CMV), parvovirus B19, or human immunodeficiency virus (HIV)
History of taking certain medications
Exposure to certain toxins, such as heavy metals
Exposure to radiation
History of an autoimmune disease, such as lupus
A developing acute lymphocytic leukemia
Children may also inherit a disorder that predisposes them to developing aplastic anemia. Some disorders that are known to predispose a child to aplastic anemia include:
Familial aplastic anemias
The following are the most common symptoms of aplastic anemia. However, each child may experience symptoms differently. Symptoms may include:
Shortness of breath
Lack of energy or tiring easily (fatigue)
Abnormal paleness or lack of color of the skin
Blood in stool
Enlarged liver or spleen
Oral thrush (white patches on a red, moist, swollen surface, occurring anywhere in the mouth)
The symptoms of aplastic anemia may resemble other blood disorders or medical problems. Always consult your child's doctor for a diagnosis.
In addition to a complete medical history and physical examination of your child, diagnostic procedures for aplastic anemia may include:
Bone marrow aspiration and/or biopsy. A procedure that involves taking a small amount of bone marrow fluid (aspiration) and/or solid bone marrow tissue called a core biopsy, usually from the hip bones, to be examined for the number, size, and maturity of blood cells and/or abnormal cells. In aplastic anemia typically the marrow is replaced by fat.
Specific treatment for aplastic anemia will be determined by your child's doctor based on:
Your child's age, overall health, and medical history
The extent of the anemia
Cause of the anemia
Your child's tolerance for specific medications, procedures, or therapies
Expectations for the course of the anemia
Your opinion or preference
Aplastic anemia is a serious illness and treatment usually depends on the underlying cause. For certain causes, recovery can be expected after treatment; however, relapses can occur. To treat the low blood counts, initial treatment is usually supportive, meaning that it is necessary to treat the symptoms but not possible to cure the disease. Supportive therapy may include:
Blood transfusion (both red blood cells and platelets)
Preventative antibiotic therapy
Special care to food preparation (such as only eating well-cooked foods)
Hormones or medications (to stimulate the bone marrow to produce cells)
Activities which put children with aplastic anemia at risk for infection or bleeding should be avoided. These activities include things like the following:
Dental work (until your child's white blood cell counts rise)
Contact sports (for example, football, hockey, skiing, or rollerblading)
Traveling to high altitudes (children with a low red blood cell count will have increased fatigue and need for oxygen in high altitudes)
If a child has a relapse of aplastic anemia, additional treatment (including a possible bone marrow transplant) may be necessary.