MC 5640
Stanford, CA 94305
Teléfono: (650) 723-6412
Facsímil: (650) 725-8544
Facsímil: (650) 725-8544
Information about the 2019 Novel Coronavirus. Read the latest >
Información sobre el coronavirus 2019 (COVID-19). Aprenda más >
Janice Man, MD
- Clinical Assistant Professor
Especialidades médicas y/o especialidades quirúrgicas
Anesthesia
Trabajo y educación
Educación
Yale School Of Medicine, New Haven, CT, 05/31/2011
Primeros años de residencia
California Pacific Medical Center Dept of Medicine, San Francisco, CA, 6/24/2012
Últimos años de residencia
University of California San Francisco, San Francisco, CA, 6/30/2015
Subespecialidad
Childrens Hospital of Philadelphia Pediatric Pathology, Philadelphia, PA, 6/30/2016
Certificado(s) de especialidad
Anesthesia, American Board of Anesthesiology
Pediatric Anesthesia, American Board of Anesthesiology
Todo Publicaciones
Technique Utilizing a Modified Oral Ring-Adair-Elwyn Tube to Provide Continuous Oxygen and Sevoflurane Delivery During Nasotracheal Intubation in an Infant With a Difficult Airway: A Case Report. A&A practice 2018; 10 (10): 25457
Abstract
Managing the airway of an infant with Pierre Robin sequence (PRS) is particularly challenging for anesthesiologists. Patients with PRS have the triad of micrognathia, glossoptosis, and airway obstruction that potentially and frequently leads to difficulty with both ventilation and intubation. Thus continuous oxygenation and spontaneous ventilation during intubation are essential. We describe a new method to deliver continuous oxygen and volatile anesthetic during nasotracheal intubation in an infant with PRS.
View details for PubMedID 29757793
Technique Utilizing a Modified Oral Ring-Adair-Elwyn Tube to Provide Continuous Oxygen and Sevoflurane Delivery During Nasotracheal Intubation in an Infant With a Difficult Airway: A Case Report. A & A case reports 2017
Abstract
Managing the airway of an infant with Pierre Robin sequence (PRS) is particularly challenging for anesthesiologists. Patients with PRS have the triad of micrognathia, glossoptosis, and airway obstruction that potentially and frequently leads to difficulty with both ventilation and intubation. Thus continuous oxygenation and spontaneous ventilation during intubation are essential. We describe a new method to deliver continuous oxygen and volatile anesthetic during nasotracheal intubation in an infant with PRS.
View details for DOI 10.1213/XAA.0000000000000677
View details for PubMedID 29210721
A retrospective comparison of thoracic epidural infusion and multimodal analgesia protocol for pain management following the minimally invasive repair of pectus excavatum. Paediatric anaesthesia 2017; 27 (12): 122734
Abstract
Pain management following minimally invasive repair of pectus excavatum is variable. We recently adopted a comprehensive multimodal analgesic protocol that standardizes perioperative analgesic management. We hypothesized that patients managed with this protocol would use more opioids postoperatively, have similar pain control, and shorter length of stay compared to patients managed with thoracic epidural infusion.We retrospectively compared opioid consumption, pain scores, and length of stay between a cohort of patients managed with our multimodal analgesic protocol and a cohort managed with a thoracic epidural infusion.This retrospective cohort comparison includes patients, 8 to 21 years of age, managed with either thoracic epidural infusion (n = 21) or multimodal analgesic protocol (n = 29) following minimally invasive repair of pectus excavatum from January 1, 2011 through September 15, 2015. The primary outcome, total daily opioid consumption in morphine equivalents, is presented as an average by postoperative day. Secondary outcomes included median daily pain score and length of stay.Patients were similar in age, weight, sex, and physical status. Patients managed with thoracic epidural infusion received less opioid (morphine equivalents-mg/kg) intraoperatively compared to multimodal analgesic protocol (difference of mean [95% confidence interval] 0.22 [0.16-0.28] P .01) but required more total opioid through postoperative day 3 (difference of mean [95% confidence interval] 1.2 [0.26-2.14] P = .01). We did not observe a difference in pain scores. Median length of stay was 1 day less in patients managed with multimodal analgesic protocol (difference of median [95% confidence interval] 1 [0.3-1.7] P = .003).Implementation of a standardized comprehensive multimodal analgesic protocol following minimally invasive repair of pectus excavatum resulted in equivalent analgesia with a modest reduction in length of stay when compared to thoracic epidural. We did not observe an opioid sparing effect in our thoracic epidural which may reflect technique variability.
View details for PubMedID 29063665
The role of CD8(+) T-cell replicative senescence in human aging IMMUNOLOGICAL REVIEWS 2005; 205: 147-157
Abstract
The strict limit in proliferative potential of normal human somatic cells - a process known as replicative senescence - is highly relevant to the immune system, because clonal expansion is fundamental to adaptive immunity. CD8(+) T cells that undergo extensive rounds of antigen-driven proliferation in cell culture invariably reach the end stage of replicative senescence, characterized by irreversible cell-cycle arrest and a critically short telomere length. Cultures of senescent CD8(+) T cells also show resistance to apoptosis, permanent loss of CD28 expression, altered cytokine profiles, reduced ability to respond to stress, and various functional changes. Cells with similar characteristics accumulate during normal aging as well as in younger persons infected with human immunodeficiency virus, suggesting that the process of replicative senescence is not an artifact of cell culture but is also occurring in vivo. Interestingly, in elderly persons, the presence of high proportions of CD8(+) T cells with characteristics of replicative senescence is correlated with reduced antibody responses to vaccines as well as with osteoporotic fractures. CD8(+)CD28(-) T cells also accumulate in patients with certain types of cancer. The emerging picture is that senescent CD8(+) T cells may modulate both immune and non-immune functions, contributing not only to reduced anti-viral immunity but also to diverse age-related pathologies.
View details for Web of Science ID 000228976300012
View details for PubMedID 15882351
Sobre
Encontrar
- © 2021 Stanford Children's Health
