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Elizabeth Talley, MD

  • “The art of medicine is taking care of people and truly listening to them.”

Medicine is two things to me: It's a science, which can be taught, and an art, which is very hard to teach. The art of medicine is taking care of people and truly listening to them.

What I really love most about my job is working with patients and their families. Even though there are many times where I can't change the situation or take the disease away, I want families to know that I'll always be there to walk them through tough situations and to support them. Knowing that someone truly cares about your child makes all the difference.

I feel so blessed that I get to make such a positive difference in a young person's life. One of my patients who had a kidney transplant just graduated from eighth grade. I went to her graduation ceremony, and she thanked me for always being there for her and supporting her. Knowing that I'm able to help in that way is truly rewarding. It doesn't get much better than that.

Specialties

Nephrology

Work and Education

Professional Education

University of Kansas School of Medicine, Kansas City, KS, 2002

Residency

Children's Hospital of Oakland, Oakland, CA, 2005

Fellowship

Lucile Packard Children's Hospital, Palo Alto, CA, 2009

Board Certifications

Pediatric Nephrology, American Board of Pediatrics

Pediatrics, American Board of Pediatrics

Conditions Treated

Kidney Transplant

Wilms Tumor

All Publications

Progression of Proliferative Glomerulonephritis with Monoclonal IgG Deposits in Pediatric Patients Miller, P., Xiao, A., Kung, V., Sibley, R., Higgins, J., Kambham, N., Charu, V., Lenihan, C., Talley, E., Walavalkar, V., Laszik, G., Arora, N., Nast, C., Troxell, M. NATURE PUBLISHING GROUP. 2020: 158990
Progression of Proliferative Glomerulonephritis with Monoclonal IgG Deposits in Pediatric Patients Miller, P., Xiao, A., Kung, V., Sibley, R., Higgins, J., Kambham, N., Charu, V., Lenihan, C., Talley, E., Walavalkar, V., Laszik, G., Arora, N., Nast, C., Troxell, M. NATURE PUBLISHING GROUP. 2020: 158990
Progression of proliferative glomerulonephritis with monoclonal IgG deposits in pediatric patients. Pediatric nephrology (Berlin, Germany) Miller, P., Xiao, A. Y., Kung, V. L., Sibley, R. K., Higgins, J. P., Kambham, N., Charu, V., Lenihan, C., Uber, A. M., Talley, E. M., Arora, N., Walavalkar, V., Laszik, Z. G., Nast, C. C., Troxell, M. L. 2020

Abstract

Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) is a glomerular disease defined by non-organized glomerular deposits of heavy and light chain-restricted immunoglobulin and israrely reported in children.We characterized a series of nine pediatric patients from two academic centers with biopsy-proven PGNMID and additionally describe two patients with monotypic IgG in the setting of IgM deposition.Each patient presented with hematuria and/or proteinuria; however, only five had elevated serum creatinine. Prodromal or concurrent infection was identified in six patients, low C3 in five, and alternate complement pathway gene variants in two. No monoclonal serum proteins were identified in five tested patients. Seven patients had monotypic deposits composed of IgG3-, two showed IgG3-, and one each IgG1 and IgG3 with lambda dominance in the setting of IgM deposition. The glomerular pattern was predominantly mesangial proliferative or membranoproliferative glomerulonephritis (MPGN). Treatment and outcomes were variable; four patients have recent PGNMID diagnoses and therefore minimal follow up, one had relatively stable kidney function for over a decade, and six experienced kidney failure, with four receiving transplants. Recurrent deposits of the same isotype were identified in five of six transplanted kidneys, corresponding to three of four transplanted patients. One of these patients developed PGNMID recurrences in three separate kidney allografts over a 20-year disease course.Our study emphasizes the need for upfront IgG subclass investigation in pediatric mesangial or MPGN with IgG deposition and monotypic or biased light-chain staining. Furthermore, this pediatric experience suggests expanded pathogenic considerations in PGNMID. Graphical abstract.

View details for DOI 10.1007/s00467-020-04763-5

View details for PubMedID 33044675