Rm H3582 MC 5640
Stanford, CA 94305
Fax: (650) 725-0009
Wayne State University School of Medicine, Detroit, MI, 6/3/2013
UC Irvine Combined Anesthesiology/Pediatric Residency, Orange, CA, 07/02/2018
Stanford University Anesthesiology Fellowships, Stanford, CA, 07/31/2019
Anesthesia, American Board of Anesthesiology
Pediatric Anesthesia, American Board of Anesthesiology
Pediatrics, American Board of Pediatrics
View details for DOI 10.1053/j.jvca.2019.02.003
View details for PubMedID 30852093
View details for DOI 10.1007/s12630-019-01543-0
View details for PubMedID 31776896
Uptake of norepinephrine via the neuronal norepinephrine transporter is reduced in the heart during deoxycorticosterone (DOCA)-salt hypertension. We hypothesized that this was due to reduced norepinephrine transporter mRNA and/or protein expression in the stellate ganglia and heart. After 4 weeks of DOCA-salt treatment there was no change in norepinephrine transporter mRNA in either the right or the left stellate ganglia from hypertensive rats (n=5-7, p>0.05). Norepinephrine transporter immunoreactivity in the left stellate ganglion was significantly increased (n=4, p<0.05) while the right stellate ganglion was unchanged (n=4, p>0.05). Whole heart norepinephrine content was significantly reduced in DOCA rats consistent with reduced uptake function; however, when norepinephrine was assessed by chamber, a significant decrease was noted only in the right atrium and right ventricle (n=6, p<0.05). Cardiac norepinephrine transport binding by chamber revealed that it was only reduced in the left atrium (n=5-7, p>0.05). Therefore, 1) contrary to our hypothesis reduced reuptake in the hypertensive heart is not exclusively due to an overall reduction in norepinephrine transporter mRNA or protein in the stellate ganglion or heart, and 2) norepinephrine transporter regulation occurs regionally in the heart and stellate ganglion in the hypertensive rat heart.
View details for DOI 10.1016/j.autneu.2013.08.070
View details for PubMedID 24075956
View details for PubMedCentralID PMC3883044