nutch_noindex
CANCEL
COVID-2019 Alert

The latest information about the 2019 Novel Coronavirus, including vaccine clinics for 12-17 year-olds.

La información más reciente sobre el nuevo Coronavirus de 2019, incluidas las clínicas de vacunación para jóvenes de 12 a 17 años.

/nutch_noindex

Talal Seddik, MD

  • “I partner with families to develop an evidence-based plan for their child.”

I've always wanted to be a pediatrician because it is a way for me to help both children and their families while making a long-lasting impact on their lives. Most infections are treatable or will resolve on their own without treatment, so patients with infections often get better, which is very rewarding. As an infectious diseases specialist, my job is to determine if a child has an infection and, if not, to help guide further steps toward an alternate diagnosis. I partner with families and use an evidence-based, scientific approach to develop a plan to treat illnesses that could be caused by infectious agents. Infections are common causes of morbidity and mortality worldwide, so small interventions like immunizations or antimicrobial agents can carry large benefits across the globe.

Specialties

Infectious Diseases

Work and Education

Professional Education

Cairo University Faculty of Medicine Office of the Registrar, Cairo, Egypt, 11/1/2009

Residency

University of Florida at Sacred Heart Pediatric Residency, Pensacola, FL, 6/30/2015

Fellowship

Stanford University Pediatric Infectious Disease Fellowship, Stanford, CA, 6/30/2018

Board Certifications

Pediatric Infectious Diseases, American Board of Pediatrics

Pediatrics, American Board of Pediatrics

All Publications

Meningitis due to Roseomonas in an immunocompetent adolescent. Access microbiology Waris, R. S., Ballard, M., Hong, D., Seddik, T. B. 2021; 3 (3): 000213

Abstract

Both bacterial and aseptic meningitis can complicate neurosurgery, but they are often difficult to distinguish clinically or by cerebrospinal fluid (CSF) analysis. We present an adolescent with subacute meningitis after neurosurgery, eventually diagnosed with meningitis caused by Roseomonas mucosa via 16S rRNA gene sequencing after two negative CSF cultures. He was treated successfully with intravenous meropenem with full recovery. This case shows that distinguishing bacterial from aseptic meningitis is important to allow directed antibiotic therapy. We recommend considering bacterial meningitis in the differential diagnosis of aseptic meningitis complicating neurosurgery, and to perform molecular diagnostics such as bacterial sequencing if the suspicion of bacterial meningitis is high.

View details for DOI 10.1099/acmi.0.000213

View details for PubMedID 34151165

Reducing Piperacillin and Tazobactam Use for Pediatric Perforated Appendicitis. The Journal of surgical research Seddik, T. B., Rabsatt, L. A., Mueller, C. n., Bassett, H. K., Contopoulos-Ioannidis, D. n., Bio, L. L., Anderson, V. D., Schwenk, H. T. 2020; 260: 14148

Abstract

Although perforated appendicitis is associated with infectious complications, the choice of antibiotic therapy is controversial. We assess the effectiveness and safety of an intervention to reduce piperacillin and tazobactam (PT) use for pediatric acute perforated appendicitis.This is a single-center, retrospective cohort study of children18y of age who underwent primary appendectomy for perforated appendicitis between January 01, 2016 and June 30, 2019. An intervention to decrease PT use was implemented: the first phase was provider education (April 19, 2017) and the second phase was modification of electronic antibiotic orders to default to ceftriaxone and metronidazole (July 06, 2017). Preintervention and postintervention PT exposure, use of PThalf of intravenous antibiotic days, and clinical outcomes were compared.Forty children before and 109 after intervention were included and had similar baseline characteristics. PT exposure was 31 of 40 (78%) and 20 of 109 (18%) (P<0.001), and usehalf of intravenous antibiotic days was 31 of 40 (78%) and 14 of 109 (13%) (P<0.001), in the preintervention and postintervention groups, respectively. There was no significant difference in mean duration of antibiotic therapy (10.8 versus 9.8d), mean length of stay (6.2 versus 6.5d), rate of surgical site infection (10% versus 11%), or rate of 30-d readmission and emergency department visit (20% versus 20%) between the preintervention and postintervention periods, respectively.Provider education and modification of electronic antibiotic orders safely reduced the use of PT for pediatric perforated appendicitis.

View details for DOI 10.1016/j.jss.2020.11.067

View details for PubMedID 33340867

Risk Factors of Ambulatory Central Line-Associated Bloodstream Infection in Pediatric Short Bowel Syndrome. JPEN. Journal of parenteral and enteral nutrition Seddik, T. B., Tian, L., Nespor, C., Kerner, J., Maldonado, Y., Gans, H. 2019

Abstract

BACKGROUND: Children with short bowel syndrome (SBS) receiving home parenteral nutrition (HPN) are predisposed to ambulatory central line-associated bloodstream infection (A-CLABSI). Data describing risk factors of this infection in children are limited.METHODS: Retrospective cohort, single-center, case-crossover study of children 18 years old with SBS receiving HPN from January 2012 to December 2016. Univariate and multivariate mixed effect Poisson regression identified the relative risk (RR) of A-CLABSI with proposed risk factors.RESULTS: Thirty-five children were identified; median follow-up was 30 months. A-CLABSI rate was 4.2 per 1000 central line (CL) days. Univariate analysis identified younger age (RR: 0.92 per 12-month increase [95% confidence interval {CI}: 0.85-0.99; P = 0.036]), shorter small intestine length (RR: 0.96 per 10-cm increase [95% CI: 0.92-0.99; P = 0.008]), lower citrulline level (RR: 0.86 per 5-nmol/mL increase [95% CI: 0.75-0.99; P = 0.036]), and recent CL break (RR: 1.55 [95% CI: 1.06-2.28; P = 0.024]) as risk factors for A-CLABSI. Multivariate analysis showed increased A-CLABSI with clinical diagnosis of small intestine bacterial overgrowth (SIBO) (RR: 1.87 [95% CI: 1.1-3.17; P = 0.021]) and CL breaks (RR: 1.49 [95% CI: 1-2.22; P = 0.024]).CONCLUSIONS: Factors influencing gut integrity increase A-CLABSI rate, supporting translocation as an important mechanism and target for prevention. Clinical diagnosis of SIBO increases A-CLABSI rate, but whether dysbiosis or diarrhea is responsible is an area for future research. CL maintenance is crucial, and prevention of breaks would likely decrease A-CLABSI rate.

View details for DOI 10.1002/jpen.1667

View details for PubMedID 31179578