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Katherine McCallie, MD

  • Katherine R McCallie


Neonatal-Perinatal Medicine

Work and Education

Professional Education

Perelman School of Medicine University of Pennsylvania, Philadelphia, PA, 06/01/2002


University of Washington Pediatric Residency, Seattle, WA, 06/30/2003


University of Washington Pediatric Residency, Seattle, WA, 06/30/2005


Stanford University Neonatology Fellowship, Palo Alto, CA, 06/30/2010

Board Certifications

Neonatal-Perinatal Medicine, American Board of Pediatrics

Pediatrics, American Board of Pediatrics



All Publications

Skin-to-skin contact after birth and the natural course of neurosteroid levels in healthy term newborns. Journal of perinatology McCallie, K. R., Gaikwad, N. W., Castillo Cuadrado, M. E., Aleman, M., Madigan, J. E., Stevenson, D. K., Bhutani, V. K. 2017


To determine the postnatal course of neurosteroid levels in relation to gender, mode of delivery and the extent of skin-to-skin (STS) contact during the first days of life in healthy term newborns.Prospective observational study of 39 neonates in which parents recorded total duration of STS in the first 2 days and nine neurosteroids (dehydroepiandrosterone-sulfate, progesterone, pregnenolone, pregnenolone-sulfate, allopregnanolone, isopregnanolone, epipregnanolone, pregnanolone and pregnanolone-sulfate) were assayed from blood samples at birth and at 1-2 days of age.All nine neurosteroid levels declined significantly during the first 2 days of life. Gender did not significantly affect the change in neurosteroid levels. The decline in neurosteroid levels was generally more pronounced in vaginal deliveries, and there was a trend toward a larger decline with more exposure to STS.Ongoing studies may better characterize the role of neurosteroids and the influence of STS in more critically ill and premature neonates.

View details for DOI 10.1038/jp.2016.268

View details for PubMedID 28102853

Feeding Protocols for VLBW Infants Neonatology: Clinical Practice and Procedures McCallie, K. edited by Stevenson, D., Cohen, R., Sunshine, P. McGraw-Hill Education. 2015; 1st ed.: 10171020
Inhaled Nitric Oxide Neonatology: Clinical Practice and Procedures McCallie, K., Van Meurs, K. edited by Stevenson, D., Cohen, R., Sunshine, P. McGraw-Hill Education. 2015; 1st ed.: 11251127


The objective of this study was to evaluate the impact of a standardized enteral feeding protocol for very low birth weight (VLBW) infants on nutritional, clinical and growth outcomes.Retrospective analysis of VLBW cohorts 9 months before and after initiation of a standardized feeding protocol consisting of 6-8 days of trophic feedings, followed by an increase of 20ml/kg/day. The primary outcome was days to reach full enteral feeds defined as 160ml/kg/day. Secondary outcomes included rates of necrotizing enterocolitis and culture-proven sepsis, days of parenteral nutrition and growth end points.Data were analyzed on 147 VLBW infants who received enteral feedings, 83 before ('Before') and 64 subsequent to ('After') feeding protocol initiation. Extremely low birth weight (ELBW) infants in the After group attained enteral volumes of 120ml/kg/day (43.9 days Before vs 32.8 days After, P=0.02) and 160ml/kg/day (48.5 days Before vs 35.8 days After, P=0.02) significantly faster and received significantly fewer days of parenteral nutrition (46.2 days Before vs 31.3 days After, P=0.01). Necrotizing enterocolitis decreased in the After group among VLBW (15/83, 18% Before vs 2/64, 3% After, P=0.005) and ELBW infants (11/31, 35% Before vs 2/26, 8% After, P=0.01). Late-onset sepsis decreased significantly in the After group (26/83, 31% Before vs 6/64, 9% After, P=0.001). Excluding those with weight <3rd percentile at birth, the proportion with weight <3rd percentile at discharge decreased significantly after protocol initiation (35% Before vs 17% After, P=0.03).These data suggest that implementation of a standardized feeding protocol for VLBW infants results in earlier successful enteral feeding without increased rates of major morbidities.

View details for DOI 10.1038/jp.2010.185

View details for Web of Science ID 000289236900010

View details for PubMedID 21448207

Feeding Premature Infants: Why, When, and What to Add to Human Milk JOURNAL OF PARENTERAL AND ENTERAL NUTRITION Cohen, R. S., McCallie, K. R. 2012; 36: 20S-24S
Neonatology Pediatrics for Medical Students Cohen, R., McCallie, K., Rhine, W. edited by Bernstein, D., Shelov, S. Lippincott Williams & Wilkins. 2012; 3rd ed.: 223250
Improved outcomes with a standardized feeding protocol for very low birth weight infants JOURNAL OF PERINATOLOGY McCallie, K. R., Lee, H. C., Mayer, O., Cohen, R. S., Hintz, S. R., Rhine, W. D. 2011; 31: S61-S67