Research and Innovation

Significant Innovations

Stanford Medicine Children’s Health’s team of PAR heart doctors regularly conduct research in pulmonary artery reconstruction. Over the last several years, we’ve developed significant innovations in care to help our PAR patients, including: 

• Creating novel (unique) approaches to the surgical management of tetralogy of Fallot (TOF) with pulmonary atresia and major aortopulmonary collateral arteries (MAPCAs), Williams syndrome, Alagille syndrome and related conditions.
• Developing and advancing methods of imaging the pulmonary arteries.

Complementing our cutting-edge care, we perform groundbreaking research on various aspects of PAR care, including:

• Improving surgical management and surgical outcomes.
• Advancing the medical management of pulmonary artery conditions.
• Improving associated respiratory, airway, and feeding problems.
• Innovative ways to replace the transcatheter pulmonary valve.
• Expanding catheter interventions on the pulmonary arteries.

Pulmonary artery reconstruction publications

Our team regularly publishes on our advancements and innovations in medical journals. Below are a number of impactful studies that helped us improve care for conditions that require pulmonary artery reconstruction in patients like you or your child. You can see our latest work via this PubMed link that consolidates research by key PAR care team members.

• Alternative to heart-lung transplantation for end-stage tetralogy of Fallot with major aortopulmonary collaterals: Simultaneous heart transplantation and pulmonary artery reconstruction.
• Programmatic Approach to Management of Tetralogy of Fallot With Major Aortopulmonary Collateral Arteries: A 15-Year Experience With 458 Patients.
• Cardiac, Aortic, and Pulmonary Vascular Involvement in Alagille Syndrome.
• Reperfusion pulmonary edema in children with tetralogy of Fallot, pulmonary atresia, and major aortopulmonary collateral arteries undergoing. unifocalization procedures: A pilot study examining potential pathophysiologic mechanisms and clinical significance.
• Early and intermediate outcomes after repair of pulmonary atresia with ventricular septal defect and major aortopulmonary collateral arteries experience with 85 patients.
• Early complete repair of pulmonary atresia with ventricular septal defect and major aortopulmonary collaterals.
• Isolated unilateral absence of right proximal pulmonary artery surgical repair and follow-up.
• Late outcomes in patients undergoing aortopulmonary window for pulmonary atresia stenosis and major aortopulmonary collaterals.
• Midline one-stage complete unifocalization and repair of pulmonary atresia with ventricular septal defect and major aortopulmonary collaterals.
• One-stage complete unifocalization in infants: When should the ventricular septal defect be closed?
• Postoperative outcomes of children with tetralogy of Fallot, pulmonary atresia, and major aortopulmonary collaterals undergoing reconstruction of occluded pulmonary artery branches.
• Pulmonary reperfusion injury after the unifocalization procedure for tetralogy of Fallot pulmonary atresia and major aortopulmonary collateral arteries.
• Surgical management of pulmonary atresia with ventricular septal defect and major aortopulmonary collateral: A protocol-based approach.
• Surgical reconstruction of peripheral pulmonary artery stenosis in Williams and Alagille syndromes.
• Surgical reconstruction of pulmonary stenosis with ventricular septal defect and major aortopulmonary collaterals.
• Surgical repair of pulmonary atresia with ventricular septal defect and major aortopulmonary collaterals with absent intrapericardial pulmonary arteries.
• Surgical outcomes for patients with pulmonary atresia/major aortopulmonary collaterals and Alagille syndrome.
• Surgical technique for repair of peripheral pulmonary artery stenosis and other complex peripheral reconstructions.
• Surgical techniques for repair of peripheral pulmonary artery stenosis.
• Tetralogy of Fallot: Aorto-pulmonary collaterals and pulmonary arteries have distinctly different transcriptomes.
• Tetralogy of Fallot with major aortopulmonary collaterals: Early total repair.
• Unifocalization of major aortopulmonary collaterals in single-ventricle patients.