Antimicrobial Stewardship Protocols

If you do not have access to any of the reference or resource documents listed on our site and would like a copy, please reach out to our team via email.

Clinical Pathways and Guidance

Guidelines for Initial Therapy for Common Pediatrics Infections (PDF) (Updated 1/2025)

Acute Leukemia Antimicrobial and Antifungal Prophylaxis Guidelines (PDF)

Antibiotic Prophylaxis in ECMO Patients: Cannulation in Sterile Setting and Cannulation in Non-Sterile Setting

Antibiotic-Loaded Bone Cement

Appendicitis Antibiotic Selection Guideline

Community Acquired Pneumonia (PDF)

Drug-Susceptible Tuberculosis Therapy Guideline (PDF) and Guide to Infection Prevention and Control Measures for TB Disease Evaluation

ENT and Plastics Peri-Operative Antibiotic Prophylaxis Guidelines

Fever in Infants (8 to 21 days old) Pathway (PDF)

Fever and Neutropenia Guidelines in Pediatric Oncology (PDF)

Liver Transplant Post-Op Antimicrobial Selection and Duration

Neonatal and Young Infant (7-60 day) Urinary Tract Infection Pathway (PDF)

NICU Late Onset Sepsis Algorithm

NICU Necrotizing Enterocolitis (NEC) Antibiotic Selection (PDF)

OB Serious Infection & Sepsis Pathway (PDF)

Pediatric Sepsis and Septic Shock Pathway (PDF)

Prolonged Fever and Neutropenia Pathway (PDF)

RSV Infant Prophylaxis: Nirsevimab (Beyfortus®) Guideline

Skin and Soft Tissue Infections  (PDF)

Stem Cell Transplant Viral Prophylaxis and Treatment Pediatric Practice Guideline

Surgical Prophylaxis Guidelines:

Urinary Tract Infections

Antimicrobial Dosing and Monitoring

Aminoglycoside Guideline and Aminoglycoside dosing strategy selection

Antimicrobial Monitoring Guidelines (PDF)

Amoxicillin-clavulanate (Augmentin®) Dosing Guide (PDF)  (Updated 1/2025)

Azole Antifungal Therapeutic Drug Monitoring Guidance (PDF)

Housestaff Manual

LPCH Blue Card – Antibiogram and Antimicrobial Dosing Quick Reference Card (PDF)

Pediatric Renal Antibiotic Dosing Recommendations

Prolonged Infusion of Beta-Lactam Guidelines (PDF)

Vancomycin per Pharmacy

Antibiotic Allergy

Antibiotic Desensitization Protocol

Antibiotic Graded Challenge Protocol

Allergy Clinical Decision Support Tool

– Antibiotic Allergy Clinical Decision Support Tool 
– Antibiotic Allergy Tool – Rationale Document  (PDF)
– Antibiotic Allergy Tool Instructions Powerpoint (PPTX)
– Video Tutorial 

Antimicrobial Restrictions

List of restricted antimicrobials at LPCH 

ASP Restricted Antimicrobial Approval Process

ASP Restricted Antimicrobial Monographs

RSV Resources

Nirsevimab Monoclonal Antibody Memo

COVID-19 Resources

Vaccination

COVID-19 Vaccine 2024-2025 Memo

Treatment

COVID-19 Inpatient Treatment Algorithm

LPCH Therapies for High-Risk Nonhospitalized Patients with Mild to Moderate COVID-19