Trio Analysis of Recurrent Pregnancy Loss Integrated Bioinformatics Genomics Study (TRIOS)

We are seeking couples who have experienced two or more clinical pregnancy losses and at least one documented chromosomally normal pregnancy loss. 

Miscarriage or pregnancy loss occurs in 10% to 20% of all pregnancies and is often unexplained by standard testing. If you have experienced two or more pregnancy losses and your testing has been normal, you and your partner may be eligible for in depth genetic testing to help us identify genetic causes of pregnancy loss. In the first phase of this study, researchers will compare DNA from mothers, fathers, and pregnancy losses to improve our understanding of novel genetic causes of miscarriage. If a genetic cause for your pregnancy loss is found, you will have the opportunity to receive results. In the second phase of the study, we will be examining the interaction of the genes with the maternal environment in early pregnancy to learn more about the way our genes are linked to pregnancy outcome.

You may be eligible if:

  • You have had two or more miscarriages or pregnancy losses at any gestational age with your current partner.
  • You have a normal uterine cavity.
  • You are over 18 years old.
  • Both egg and sperm providers are willing to participate.

Study participation involves:

  • Providing a DNA sample (either blood or saliva).
  • Completing an online questionnaire about your medical history.
  • Providing access to miscarriage tissue or DNA.
  • For patients planning pregnancy, up to three fasting blood samples for women and one fasting blood sample from male participants.