Conditions That Can Lead to Lung or Combined Heart-Lung Transplant

In our various clinical programs at Stanford Medicine Children’s Health, we treat a variety of end-stage lung and pulmonary vascular diseases with transplantation. Specific conditions that may require transplantation include:   

Pulmonary vascular disease

  • Pulmonary hypertension (PH)
  • Pulmonary veno-occlusive disease (PVOD)
  • Alveolar capillary dysplasia (ACD)
  • Bilateral pulmonary vein stenosis (PVS) with or without congenital heart disease

Learn more about pulmonary vascular disease >

Chronic lung disease with secondary pulmonary hypertension

Learn more about advanced lung disease >

Primary pulmonary disease

  • Cystic fibrosis (CF)
  • Heritable surfactant deficiencies, including but not limited to:
    • Surfactant protein B
    • Surfactant protein C
    • NKX2.1 disease (brain-thyroid-lung syndrome)
    • ABCA3 deficiency
  • Obliterative bronchiolitis or bronchiolitis obliterans
  • Chronic lung graft versus host disease (GVHD) after stem cell transplant
  • Pulmonary fibrosis
  • Bronchiectasis (not CF-related)
  • Chronic lung failure after acute respiratory distress syndrome

Pulmonary disease with a vascular component

  • FLNA (Filamin A gene) disease
  • TBX4 disease

Congenital heart disease